Podocyte infolding glomerulopathy masquerading as membranous nephropathy - a shared pathogenesis?
Author
Matthai, Smita MaryHems, Liam
Tsang, Yee Wah
Aggarwal, Yogita
Mahmoud, Huda
Gopalakrishnan, Kishore
Affiliation
Christian Medical College; University Hospitals Coventry and Warwickshire NHS Trust; Walsall Healthcare NHS TrustPublication date
2024-08-01Subject
Nephrology/Renal medicine
Metadata
Show full item recordAbstract
Podocyte infolding glomerulopathy (PIG) is a rare pathological entity, diagnosed by electron microscopic demonstration of diffuse infolding of the podocytes into the glomerular basement membranes. We report the first case from United Kingdom exhibiting typical ultrastructural features of PIG in a male with Type II diabetes mellitus, hypertension and common variable immune deficiency. Renal biopsy revealed phospholipase A2 receptor (PLA2R) immunostain positive membranous nephropathy (MN) but no serum PLA2R antibodies. Diffuse infolding of the podocytes into the glomerular basement membranes along with pathognomonic microspherular and microtubular intra basement membrane clusters distributed diffusely and globally were noted on electron microscopy, diagnostic of PIG. We postulate a shared pathomechanistic link between PIG and MN, highlighting the overlapping features of both conditions.Citation
Matthai SM, Hems L, Tsang YW, Aggarwal Y, Mahmoud H, Gopalakrishnan K. Podocyte Infolding Glomerulopathy Masquerading as Membranous Nephropathy - A Shared Pathogenesis? Indian J Nephrol. 2024 Jul-Aug;34(4):397-400. doi: 10.25259/ijn_209_23. Epub 2024 Jun 24. PMID: 39156853; PMCID: PMC11326786.Type
ArticlePMID
39156853Publisher
Medknow Publicationsae974a485f413a2113503eed53cd6c53
10.25259/ijn_209_23