Antimicrobial resistance : a concise update
Ho, Charlotte S Wong, Carlos T H Aung, Thet Tun Lakshminarayanan, Rajamani Mehta, Jodhbir S McNally, Alan Kintses, Balint Peacock, Sharon J de la Fuente-Nunez, Cesar
Ho, Charlotte S
Wong, Carlos T H
Aung, Thet Tun
Lakshminarayanan, Rajamani
Mehta, Jodhbir S
McNally, Alan
Kintses, Balint
Peacock, Sharon J
de la Fuente-Nunez, Cesar
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Affiliation
Western Eye Hospitall Charing Cross Hospital; Singapore Eye Research Institute; Sandwell and West Birmingham NHS Trust; et al.
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Publication date
2024-09-12
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Abstract
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive approach that ranges from increased understanding of mechanisms and drivers at the individual and population levels, AMR surveillance, antimicrobial stewardship, improved infection prevention and control measures, and strengthened global policies and funding to development of novel antimicrobial therapeutic strategies. In this rapidly advancing field, this Review provides a concise update on AMR, encompassing epidemiology, evolution, underlying mechanisms (primarily those related to last-line or newer generation of antibiotics), infection prevention and control measures, access to antibiotics, antimicrobial stewardship, AMR surveillance, and emerging non-antibiotic therapeutic approaches. The Review also discusses the potential roles of artificial intelligence in addressing AMR, including antimicrobial susceptibility testing, AMR surveillance, antimicrobial stewardship, diagnosis, and antimicrobial drug discovery and development. This Review highlights the urgent need for addressing the global effects of AMR and for rapid advancement of relevant technology in this dynamic field.
Citation
Ho CS, Wong CTH, Aung TT, Lakshminarayanan R, Mehta JS, Rauz S, McNally A, Kintses B, Peacock SJ, de la Fuente-Nunez C, Hancock REW, Ting DSJ. Antimicrobial resistance: a concise update. Lancet Microbe. 2024 Sep 12:100947. doi: 10.1016/j.lanmic.2024.07.010. Epub ahead of print. PMID: 39305919.
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Article