Low serum vitamin B12 levels are associated with adverse lipid profiles in apparently healthy young Saudi women
Author
Al-Musharaf, SaraAljuraiban, Ghadeer S
Hussain, Syed Danish
Alnaami, Abdullah M
Saravanan, Ponnusamy
Al-Daghri, Nasser
Affiliation
King Saud University, Riyadh, Saudi Arabia; University of Warwick; George Eliot Hospital, NuneatonPublication date
2020-08-10
Metadata
Show full item recordAbstract
An abnormal lipid profile is an independent risk factor for cardiovascular diseases. The relationship between vitamin B12 deficiency and lipid profile is inconclusive, with most studies conducted in unhealthy populations. In this study, we aimed to assess the relationship between serum vitamin B12 levels and lipid profiles in a cross-sectional study that included 341 apparently healthy Saudi women, aged 19-30 years, from different colleges at King Saud University, Saudi Arabia. Sociodemographic, anthropometric, biochemical, and lifestyle data were collected, including diet and physical activity. Serum vitamin B12 deficiency was defined as serum B12 level of <148 pmol/L. The prevalence of vitamin B12 deficiency was approximately 0.6%. Using multivariable linear regression models, serum vitamin B12 levels were found to be inversely associated with total cholesterol (B = -0.26; p < 0.001), low-density lipoprotein cholesterol levels (B = -0.30; p < 0.001), and triglyceride (B = -0.16; p < 0.01) after adjusting for potential confounders, while obesity indices of body mass index, central obesity, and fat percentage showed no association. Therefore, we conclude that low serum vitamin B12 levels are independently associated with abnormal lipid profiles in healthy young Saudi women. Further interventional studies are needed to determine whether improving serum vitamin B12 levels in a healthy population can improve lipid profiles.Citation
Al-Musharaf S, Aljuraiban GS, Danish Hussain S, Alnaami AM, Saravanan P, Al-Daghri N. Low Serum Vitamin B12 Levels Are Associated with Adverse Lipid Profiles in Apparently Healthy Young Saudi Women. Nutrients. 2020 Aug 10;12(8):2395. doi: 10.3390/nu12082395.Type
ArticleAdditional Links
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7468727/PMID
32785129Journal
NutrientsPublisher
MDPIae974a485f413a2113503eed53cd6c53
10.3390/nu12082395