Neurodevelopmental outcomes following paracetamol use for treatment of patent ductus arteriosus: a review.
Abstract
Aim: Concerns exist regarding potential adverse neurodevelopmental outcomes associated with paracetamol exposure during pregnancy and early infancy. This review evaluates the evidence for the impact of paracetamol use for patent ductus arteriosus (PDA) treatment on neurodevelopmental outcomes in preterm infants. Methods: A literature search was performed via Medline, Ovid Embase and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases. The search details are below: ('Infant, Newborn' [MeSH] OR 'neonate*' [Title/Abstract]) AND ('Paracetamol' [MeSH] OR 'Acetaminophen' [Title/Abstract]) AND ('Ductus Arteriosus, Patent/drug therapy' [MeSH] OR 'patent ductus arteriosus' [Title/Abstract]) AND ('Neurodevelopmental Disorders' [MeSH] OR 'neurodevelopment*' [Title/Abstract] OR 'Child Development' [MeSH] OR 'Developmental Disabilities' [MeSH]). All studies were critically appraised and synthesised. Results: Seven studies reported neurodevelopmental outcomes after paracetamol use for PDA treatment in preterm infants <32 weeks gestation. The studies varied in dosage, route, and duration of paracetamol administration and in the methods used to assess neurodevelopmental outcomes. None of the studies revealed different outcomes between paracetamol-exposed preterm infants and controls. Conclusion: Current low-to-moderate quality evidence suggests no association between paracetamol used for PDA treatment and adverse neurodevelopmental outcomes in preterm infants. Future well-powered studies with standardised neurodevelopmental assessments are warranted to strengthen the current evidence base.Citation
Pearce A, Saunders L, Dunlop A, Abbas A. Neurodevelopmental outcomes following paracetamol use for treatment of patent ductus arteriosus: A review. Acta Paediatr. 2024 Sep 3. doi: 10.1111/apa.17415. Epub ahead of printType
ArticleOther
Additional Links
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1651-2227PMID
39225273Journal
Acta PaediatricaPublisher
Wiley-Blackwellae974a485f413a2113503eed53cd6c53
10.1111/apa.17415