The contribution of autophagy and lncRNAs to MYC-driven gene regulatory networks in cancers
Author
Jahangiri, LeilaPucci, Perla
Ishola, Tala
Trigg, Ricky M
Williams, John A
Pereira, Joao
Cavanagh, Megan L
Turner, Suzanne D
Gkoutos, Georgios V
Tsaprouni, Loukia
Publication date
2021-08-08
Metadata
Show full item recordAbstract
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.Citation
Jahangiri L, Pucci P, Ishola T, Trigg RM, Williams JA, Pereira J, Cavanagh ML, Turner SD, Gkoutos GV, Tsaprouni L. The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers. Int J Mol Sci. 2021 Aug 8;22(16):8527. doi: 10.3390/ijms22168527Type
ArticleOther
Additional Links
http://www.mdpi.com/journal/ijmsPMID
34445233Publisher
MDPIae974a485f413a2113503eed53cd6c53
10.3390/ijms22168527