Using Climate-HIV to describe real-world clinical outcomes for people living with HIV taking dolutegravir-based regimens.
Author
Okoli, ChinyereSchwenk, Achim
Radford, Matthew
Myland, Melissa
Taylor, Stephen
Barnes, Justine
Fox, Ashini
Darley, Alison
Grimson, Fiona
Reeves, Iain
Munshi, Sajid
Croucher, Adam
Boxall, Naomi
Paice, Alistair
van Wyk, Jean
Benn, Paul
Publication date
2021-06-22Subject
Microbiology. Immunology
Metadata
Show full item recordAbstract
Objectives: The objective of this study was to describe the real-world use and effectiveness of dolutegravir-based regimens (DBRs) in routine clinical practice in the United Kingdom. Methods: Retrospective analysis was conducted using data from four National Health Service trusts using Climate-HIV, an electronic case record system. Eligible patients were aged ≥18 years with HIV-1 infection who were prescribed a DBR from December 2012 to March 2018. Outcome measurements were accessed at DBR initiation and at weeks 24, 48 and 96 and the last recorded visit up to the extraction date (last measurement). The primary endpoint was the proportion of patients with HIV-1 RNA <50 copies/mL at Week 48. Results: The study cohort included 934 patients; 337 (36%) were female, 414 (47%) were white and 717 (77%) were treatment experienced (TE). The Kaplan-Meier estimated probability of achieving HIV-1 RNA <50 copies/mL at 48 weeks was 96% for treatment-naive (TN) patients and 86% for TE patients. Median times to viral suppression (<50 copies/mL) were 49 and 57 days for TN and TE patients with detectable baseline viral load, respectively, according to Kaplan-Meier analysis. Median follow-up time was 377 days (interquartile range: 131-683). At last measurement, 87% (809/934) of patients remained on a DBR; among those patients, 681 (84%) had HIV-1 RNA <50 copies/mL. Conclusions: High levels of virologic suppression and low rates of discontinuation of DBRs were seen in a large, diverse, UK-based population with HIV-1 infection. These findings are broadly consistent with efficacy data from phase III studies.Citation
Okoli C, Schwenk A, Radford M, Myland M, Taylor S, Barnes J, Fox A, Darley A, Grimson F, Reeves I, Munshi S, Croucher A, Boxall N, Paice A, van Wyk J, Benn P. Using Climate-HIV to describe real-world clinical outcomes for people living with HIV taking dolutegravir-based regimens. Int J STD AIDS. 2021 Oct;32(12):1165-1173. doi: 10.1177/09564624211027099. Epub 2021 Jun 22Type
ArticleAdditional Links
https://journals.sagepub.com/home/stdPMID
34156330Publisher
Sageae974a485f413a2113503eed53cd6c53
10.1177/09564624211027099