Oculomic stratification of COVID-19 patients' intensive therapy unit admission status and mortality by retinal morphological findings
Author
Courtie, EllaTaylor, Matthew
Danks, Dominic
Acharjee, Animesh
Jackson, Thomas
Logan, Ann
Veenith, Tonny
Blanch, Richard J
Publication date
2024-09-12Subject
Diseases & disorders of systemic, metabolic or environmental originOphthalmology
Clinical pathology
Metadata
Show full item recordAbstract
To investigate if retinal thickness has predictive utility in COVID-19 outcomes by evaluating the statistical association between retinal thickness using OCT and of COVID-19-related mortality. Secondary outcomes included associations between retinal thickness and length of stay (LoS) in hospital. In this retrospective cohort study, OCT scans from 230 COVID-19 patients admitted to the Intensive Care Unit (ITU) were compared with age and gender-matched patients with pneumonia from before March 2020. Total retinal, GCL + IPL, and RNFL thicknesses were recorded, and analysed with systemic measures collected at the time of admission and mortality outcomes, using linear regression models, Pearson's R correlation, and Principal Component Analysis. Retinal thickness was significantly associated with all-time mortality on follow up in the COVID-19 group (p = 0.015), but not 28-day mortality (p = 0.151). Retinal and GCL + IPL layer thicknesses were both significantly associated with LoS in hospital for COVID-19 patients (p = 0.006 for both), but not for patients with pneumonia (p = 0.706 and 0.989 respectively). RNFL thickness was not associated with LoS in either group (COVID-19 p = 0.097, pneumonia p = 0.692). Retinal thickness associated with LoS in hospital and long-term mortality in COVID-19 patients, suggesting that retinal structure could be a surrogate marker for frailty and predictor of disease severity in this group of patients, but not in patients with pneumonia from other causes.Citation
Courtie E, Taylor M, Danks D, Acharjee A, Jackson T, Logan A, Veenith T, Blanch RJ. Oculomic stratification of COVID-19 patients' intensive therapy unit admission status and mortality by retinal morphological findings. Sci Rep. 2024 Sep 12;14(1):21312. doi: 10.1038/s41598-024-68543-z.Type
ArticleAdditional Links
https://www.nature.com/articles/s41598-024-68543-zPMID
39266635Journal
Scientific ReportsPublisher
Nature Publishing Groupae974a485f413a2113503eed53cd6c53
10.1038/s41598-024-68543-z