Socioeconomic, comorbidity, lifestyle, and quality of life comparisons between chronic rhinosinusitis phenotypes.
Author
Philpott, CarlTa, Ngan Hong
Hopkins, Claire
Ray, Jaydip
Ahmed, Shazhada
Almeyda, Robert
Kara, Naveed
Carrie, Sean
Erskine, Sally E
Cathcart, Russell
Sunkaraneni, Vishnu
Robertson, Alasdair
Anari, Shahram
Kumar, Balasubrahmanyam Nirmal
Clark, Allan
Publication date
2021-03-26Subject
Ear, Nose & Throat
Metadata
Show full item recordAbstract
Background: Chronic rhinosinusitis (CRS) is a heterogeneous group of inflammatory sinonasal disorders with key defining symptoms, but traditionally separated into phenotypes by clinical/endoscopic findings. It is not known whether the two phenotypes have differing socioeconomic, comorbidity, and lifestyle differences. This analysis of the Chronic Rhinosinusitis Epidemiology Study (CRES) database sought to analyze any key differences in the socioeconomic variables between those with CRS with nasal polyps (CRSwNPs) and those without nasal polyps (CRSsNPs). We also sought to analyze differences in comorbidities, lifestyle, and quality of life. Methods: Patients with a confirmed diagnosis of CRS in secondary and tertiary care outpatient settings in the UK were invited to participate in a questionnaire-based case-control study. Variables included demographics, socioeconomic factors, comorbidities, lifestyle factors, and health-related quality of life (HRQoL) (level 3 evidence). Results: A total of 1204 patients' data were analyzed: 553 CRSsNP and 651 CRSwNP participants. The key socioeconomic variables did not demonstrate any notable differences, nor did lifestyle variables other than alcohol consumption being higher in those with CRSwNP (P = .032), but the latter was not significant after adjusting for age and sex. Aside from confirmation of asthma being more common in CRSwNP, it was notable that this group complained less of upper respiratory tract infections (URTIs), and CRSsNP participants showed evidence of worse HRQoL scores in respect of body pain (P = .001). Conclusions: Patients with CRSwNP experience higher rates of asthma and lower rates of URTIs; patients with CRSsNP have worse body pain scores. Otherwise, there are no demonstrable significant socioeconomic, comorbidity, lifestyle, or quality of life differences between the two phenotypes. Level of evidence: 3 Laryngoscope, 131:2179-2186, 2021.Citation
Philpott C, Ta NH, Hopkins C, Ray J, Ahmed S, Almeyda R, Kara N, Carrie S, Erskine SE, Cathcart R, Sunkaraneni V, Robertson A, Anari S, Kumar BN, Clark A; CRES Group. Socioeconomic, comorbidity, lifestyle, and quality of life comparisons between chronic rhinosinusitis phenotypes. Laryngoscope. 2021 Oct;131(10):2179-2186. doi: 10.1002/lary.29527. Epub 2021 Mar 26Type
ArticleOther
Additional Links
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1531-4995PMID
33769590Journal
The LaryngoscopePublisher
Wiley-Blackwellae974a485f413a2113503eed53cd6c53
10.1002/lary.29527