Now showing items 1-20 of 452

    • Audit of compliance with AAGBI guidelines on coagulation screen requests for patients undergoing surgery for femoral fractures

      Morrish, J.; Jefferson, P.; Morrish, J.; Jefferson, P.; Anaesthetics; Medical and Dental; South Warwickshire University NHS Foundation Trust (Wiley, 2015-06-14)
      Conference abstract 67 of the Association of Anaesthetists of Great Britain and Ireland (AAGBI) Group of Anaesthetists in Training (GAT) Annual Scientific Meeting, 17–19 June 2015, Manchester, UK.
    • Aseptic precautions for caudal anaesthesia

      Maddock, A.; Ball, D. R.; Jefferson, P.; Jefferson, P.; Anaesthetics; Medical and Dental; Western Infirmary, Glasgow; Dumfries and Galloway Royal Infirmary; South Warwickshire University NHS Foundation Trust (Wiley, 2015-01-13)
      This correspondence piece highlights the low rate at which anaesthetists seemed to have adopted new guidelines and recommendations.
    • Endometrial ablation and steam vaporisation : the true first generation ablative technique

      Olah, Karl S.; Olah, Karl S.; Obstetrics and Gynaecology; Medical and Dental; South Warwickshire University NHS Foundation Trust (Wiley, 2015-11-21)
      This BJOG Perspectives article explores the history of endometrial ablation and steam vaporisation as techniques to treat women with menstrual disorders, drawing on the work of G. F. Blacker in 1902.
    • Then and now : outcomes of surgical treatment for early cervical cancer 1902

      Jeevan, David; Olah, Karl; Jeevan, David; Olah, Karl; Obstetrics and Gynaecology; Medical and Dental; South Warwickshire University NHS Foundation Trust (Wiley, 2015-09-25)
      This BJOG Perspectives article provides a historical snapshot of the surgical techniques available in the early twentieth century for the treatment of cervical cancer, drawing on the work of Thomas Wilson (BJOG. 1902;1(5):526-46. doi: 10.1111/j.1471-0528.1902.tb10544.x.).
    • Vaginal sub-total hysterectomy — an early minimally invasive procedure

      Olah, Karl S.; Olah, Karl S.; Obstetrics and Gynaecology; Medical and Dental; South Warwickshire University NHS Foundation Trust (Wiley, 2015-11-21)
      This BJOG Perspectives article summarises an early minimally invasive procedure developed by Arthur J. Wallace (1867–1913).
    • Fournier's gangrene secondary to an acutely inflamed appendix herniating into the deep inguinal ring

      Sarmah, Piyush B.; Khan, Mashuk; Zilvetti, Miguel; Khan, Mashuk; General Surgery; Medical and Dental; City Hospital, Birmingham; South Warwickshire University NHS Foundation Trust; Worcestershire Royal Hospital (Oxford University Press, 2015-03-31)
      Fournier's gangrene (FG) requires prompt recognition and management. We report the case of a 68-year-old man who presented with extensive pain and purple discolouration from the right iliac fossa to perineum. Computed tomography demonstrated gas within the right hemiscrotum extending into the inguinal canal and right buttock, with a right pelvic fluid and air collection. At debridement necrotic fluid was arising from the superficial inguinal ring so laparotomy was performed, revealing a grossly inflamed appendix herniating into the inguinal canal; a right hemicolectomy was performed. Unfortunately, the patient went into cardiac arrest and passed away on the operating table. Histological analysis demonstrated acute-on-chronic inflammation involving the appendix. The condition where appendicitis is implicated in FG is usually due to retroperitoneal rupture and tracking into the perineal spaces. This is the first case reported of an inflamed appendix herniating into the inguinal canal and thus causing FG.
    • Quantitative assessment of multiorgan sequestration of parasites in fatal pediatric cerebral malaria

      Milner, Danny A. Jr; Lee, Jonathan J.; Frantzreb, Charles; Whitten, Richard O.; Kamiza, Steve; Carr, Richard; Pradham, Alana; Factor, Rachel E.; Playforth, Krupa; Liomba, George; et al. (Oxford University Press, 2015-04-07)
      Children in sub-Saharan Africa continue to acquire and die from cerebral malaria, despite efforts to control or eliminate the causative agent, Plasmodium falciparum. We present a quantitative histopathological assessment of the sequestration of parasitized erythrocytes in multiple organs obtained during a prospective series of 103 autopsies performed between 1996 and 2010 in Blantyre, Malawi, on pediatric patients who died from cerebral malaria and controls. After the brain, sequestration of parasites was most intense in the gastrointestinal tract, both in patients with cerebral malaria and those with parasitemia in other organs. Within cases of histologically defined cerebral malaria, which includes phenotypes termed "sequestration only" (CM1) and "sequestration with extravascular pathology" (CM2), CM1 was associated with large parasite numbers in the spleen and CM2 with intense parasite sequestration in the skin. A striking histological finding overall was the marked sequestration of parasitized erythrocytes across most organs in patients with fatal cerebral malaria, supporting the hypothesis that the disease is, in part, a result of a high level of total-body parasite sequestration. Keywords: Africa; Malawi; autopsy; cerebral malaria; pathology; pediatrics
    • Standard care practices and psychosocial interventions aimed at reducing parental distress following stillbirth : a systematic narrative review

      Crispus Jones, Helen; McKenzie-McHarg, Kirstie; Horsch, Antje; McKenzie-McHarg, Kirstie; Clinical Health Psychology; Additional Professional Scientific and Technical Field; Looked After Children's Psychology Service, Ealing; South Warwickshire University NHS Foundation Trust; University Hospital Lausanne, Switzerland (Taylor and Francis Group, 2015-05-22)
      Objective: To summarise and critically evaluate the evidence informing the provision of standard care practices and psychosocial interventions following stillbirth. Background: Stillbirth is increasingly recognised as a significant bereavement experience with the potential to cause substantial psychological distress for parents. Standard care practices and psychosocial interventions to support parents have undergone dramatic changes, with limited basis in evidence. Methods: A systematic narrative review was conducted of quantitative studies examining interventions designed to reduce psychological distress in parents following the loss of a stillborn baby. Results: Twenty-five studies met the inclusion criteria for the review. Substantial methodological weaknesses were identified among reviewed studies, including small and heterogeneous loss samples, weak study designs and lack of clarity in reported methods and outcomes. Inadequate replication of many findings substantially limits the generalisability of the evidence. Conclusion: Tentative evidence was found for the provision of mementoes of the baby and information regarding the cause of the loss, support group attendance, and cognitive behavioural interventions for parents identified with clinical levels of distress. Contradictory findings for the impact of contact with the baby prevent the formation of clear conclusions for this practice. Due to the methodological weaknesses prevalent in the research identified, the current evidence base is not considered sufficiently able to reliably inform care practices and intervention approaches. High-quality research evidence in this field is urgently required. Keywords: stillbirth; perinatal loss; interventions; care; evidence-based practice; parents
    • Post-traumatic stress disorder following childbirth : an update of current issues and recommendations for future research

      McKenzie-McHarg, Kirstie; Ayers, Susan; Ford, Elizabeth; Horsch, Antje; Jomeen, Julie; Sawyer, Alexandra; Stramrood, Claire; Thomson, Gill; Slade, Pauline; McKenzie-McHarg, Kirstie; et al. (Taylor and Francis Group, 2015-04-28)
      Objective: This paper aimed to report the current status of research in the field of post-traumatic stress disorder following childbirth (PTSD FC), and to update the findings of an earlier 2008 paper. Background: A group of international researchers, clinicians and service users met in 2006 to establish the state of clinical and academic knowledge relating to PTSD FC. A paper identified four key areas of research knowledge at that time. Methods: Fourteen clinicians and researchers met in Oxford, UK to update the previously published paper relating to PTSD FC. The first part of the meeting focused on updating the four key areas identified previously, and the second part on discussing new and emerging areas of research within the field. Results: A number of advances have been made in research within the area of PTSD FC. Prevalence is well established within mothers, several intervention studies have been published, and there is growing interest in new areas: staff and pathways; prevention and early intervention; impact on families and children; special populations; and post-traumatic growth. Conclusion: Despite progress, significant gaps remain within the PTSD FC knowledge base. Further research continues to be needed across all areas identified in 2006, and five areas were identified which can be seen as ‘new and emerging’. All of these new areas require further extensive research. Relatively little is still known about PTSD FC. Keywords: PTSD, childbirth, review, theory, research
    • Post-traumatic stress disorder after birth

      Ayers, Susan; McKenzie-McHarg, Kirstie; Slade, Pauline; McKenzie-McHarg, Kirstie; Clincal Health Psychology; Additional Professional Scientific and Technical Field; City University London; South Warwickshire University NHS Foundation Trust; University of Liverpool (Taylor and Francis Group, 2015-04-17)
      This Special Issue Editorial reviews the development of post-traumatic stress disorder (PTSD) in women in response to difficult or traumatic birth experiences, and the interventions available.
    • Acquired isodisomy on chromosome 13 at diagnosis results in impaired overall survival in patients with FLT3-ITD mutant acute myeloid leukaemia

      Loke, J. C. T.; Akiki, S.; Borrow, J.; Ewing, J.; Bokhari, S. W.; Chandra, D.; Arrazi, J.; Hazlewood, P.; Arthur, K.; Walsh, J.; et al. (Springer Nature, 2015-06-19)
      Internal tandem duplication (ITD) mutations in the FLT3 gene on chromosome 13 occur in 25% of patients with acute myeloid leukaemia (AML) and result in impaired overall survival (OS). Patients with a high allelic ratio (AR) of ITD mutant to wild-type FLT3 in genomic DNA have an even poorer prognosis. AR may be a predictor of response to FLT3 inhibitors and may also interact with other mutations in influencing disease risk. AR may be dependent on a number of factors including loss of the wild-type allele. Acquired isodisomy (AID) results in loss of the wild-type allele, through duplication of the mutant allele with segmental loss of the wild-type allele. Although studies have shown the importance of AID at chromosome 13 (AID13) at relapse, the impact of AID13 at diagnosis is unclear. The study reported in this Letter to the Editor aimed to identify the relationship between AID13 and FLT3-ITD AR and investigated the outcomes of patients with AID13.
    • Human perception of visual stimuli modulated by direction of linear polarization

      Misson, Gary; Timmerman, Brenda H.; Bryanston-Cross, Peter J.; Misson, Gary P.; Ophthalmology; Medical and Dental; South Warwickshire University NHS Foundation Trust; Vizeye Ltd, Coventry; University of Warwick (Elsevier, 2015-08-28)
      This study explores both theoretically and experimentally the human perception of polarized light beyond that currently established. The radial analyser theory of Haidinger's phenomenon (HP) is used to predict the effect of observing visual stimuli comprising patterned zones characterized by orthogonal planes of linear polarization (linear polarization direction fields, LPD-fields). Any pattern can be represented as an LPD-field including optotypes and geometric forms. Simulated percepts differ from the original patterns although edges are mostly preserved. In edge-rich images a cross of attenuating contrast spanning the field of view is predicted. The mathematical model is verified experimentally using a liquid crystal display (LCD)-based polarization modulator imaged through a tangential (azimuthal) analyser with properties complementary to a radial analyser. The LCD device is then used in vivo to elicit perceptual responses in human subjects. Normal humans are found to readily detect spatially and temporally modulated isoluminant spatially-isochromatic, highly polarized LPD stimuli. Most subjects match the stimuli to corresponding images of theoretically predicted percepts. In particular edge perception and the presence of the contrast cross was confirmed. Unlike HP, static patterned LPD stimuli are perceived without difficulty. The simplest manifestation of human polarization perception is HP which is the fundamental element of an open set of stimulus-dependent percepts. This study demonstrates that humans have the ability to perceive and identify visual pattern stimuli defined solely by polarization state modulation. Keywords: Haidinger’s brushes; Human polarization perception; Macula; Optotype; Radial analyser model.
    • Paediatric palliative care

      Thompson, Angela; Thompson, Angela; Paediatrics; Medical and Dental; South Warwickshire University NHS Foundation Trust; Zoe's Place Baby Hospice, Coventry (Elsevier, 2015-06-06)
      Children with palliative care needs are increasing in prevalence and complexity of need. 49,000 children (under 19 years) were estimated to be living in the UK in 2012 with a life limiting/life threatening condition that might require palliative care. Palliative care requires a total and active approach, with transparent, communicated, agreed provision of appropriate and proportionate care. Planning improves care, supported by documentation of plans. Advance planning enables management of both reversible and chronic aspects of the condition, as well as utilising parallel planning when end of life approaches. Challenges in palliative care include the commissioning of sustainable services across organisations to deliver, often over years, but sometimes briefly and rapidly, 24/7 access to skilled palliative care, including hands on care at the end of life. Care is integrally intertwined with other clinical, social, education and voluntary services to ensure that families receive the spectrum of care required throughout their journey. Keywords advance care; best interest; end of life; life limiting; palliative; parallel planning; planning; sustainable
    • Should patients presenting with acutely swollen knee joints be managed initially solely within the emergency department?

      Chavda, V.; Akinola, B.; Chavda, R.; Chauhan, V.; Carrothers, A.; Chauhan, V.; Medical and Dental; East Midlands South Deanery; East Anglia; University of Leicester; South Warwickshire University NHS Foundation Trust; Addenbrooke's Hospital, Cambridge (IJS Publishing GroupElsevier, 2015-11)
      Poster abstract 0642 of the Association of Surgeons in Training conference ASiT 2015, Glasgow, UK, November 2015.
    • One Step Nucleic Acid amplification testing for CK19 : single copy number >5,000 copies/μL vs Total Tumour Load of 15,000 copies/μL

      Atherton, Gavin; Tafazal, Habib; Amin, Verda; Dakka, Mahmoud; Khan, Mashuk; Harries, Simon; Jones, Lucie; Clarke, Dayalan; Atherton, Gavin; Tafazal, Habib; et al. (Elsevier, 2015-06)
      Background: The diagnostic criteria for OSNA proposes cut-off values of >5000 copies/μL of CK 19 mRNA as macro-metastases. Practice in our centre is to perform axillary node clearance (ANC) on patients with a copy number of >5000 in any node. A recent study has suggested an alternative method using the total copy number of all sentinel nodes (Total Tumour Load) with a cut-off of 15,000 copies/μL.
    • The use of SentiMag in identifying the sentinel lymph node : Warwick experience

      Tafazal, Habib; Dakka, Mahmoud; Athwal, Ruvinder; Clarke, Dayalan; Jones, Lucie; Harries, Simon; Tafazal, Habib; Dakka, Mahmoud; Athwal, Ruvinder; Clarke, Dayalan; et al. (Elsevier, 2015-06)
      Introduction: SentiMag is a new system for the detection of the sentinel lymph node (SLN) in patients with breast cancer. The new technique uses 2 devices: a subcutaneous injection of a magnetic tracer into the breast and the use of a hand-held device (a magnetometer) to detect the SLN intra-operatively. We used SentiMag and compared it to the standard technique (radioisotope alone in our unit) used in breast cancer patients. We looked at the localisation rate of SLN detected with both the standard and the SentiMag technique.
    • One-step nucleic acid amplification : CK 19 copy number as a predictor of further axillary involvement

      Tafazal, Habib; Atherton, Gavin; Amin, Verda; Dakka, Mahmoud; Park, Michael; Smith, Adrian; Harries, Simon; Jones, Lucie; Clarke, Dayalan; Tafazal, Habib; et al. (Elsevier, 2015-06)
      Introduction: In 2013, the National Institute of Clinical Excellence (NICE) endorsed the use of One step nucleic acid amplification (OSNA) in clinical practice. Our study aims to seek a correlation between the OSNA results, indicated by CK 19 mRNA copy numbers and the likelihood of non-sentinel axillary involvement in patients with macro-metastases.
    • Debriefing interventions for the prevention of psychological trauma in women following childbirth

      Bastos, Maria Helena; Furuta, Marie; Small, Rhonda; McKenzie-McHarg, Kirstie; Bick, Debra; McKenzie-McHarg, Kirstie; Clinical Health Psychology; Additional Professional Scientific and Technical Field; Fiocruz, Rio de Janeiro, Brazil; Kyoto University, Japan; Judith Lumley Centre, Melbourne, Australia; South Warwickshire University NHS Foundation Trust; King's College London (Cochrane CollaborationWiley, 2015-04-10)
      Background: Childbirth is a complex life event that can be associated with both positive and negative psychological responses. When giving birth is experienced as particularly traumatic this can have a negative impact on a woman's postnatal emotional well-being. There has been an increasing focus on women's psychological trauma symptoms following childbirth, including the relatively rare phenomenon of post-traumatic stress disorder (PTSD), and the benefit of debriefing interventions to prevent this. In this review we examined the evidence for debriefing as a preventative intervention for psychological trauma following childbirth. Objectives: To assess the effects of debriefing interventions compared with standard postnatal care for the prevention of psychological trauma in women following childbirth. Search methods: The trials registers of the Cochrane Depression, Anxiety and Neurosis Group (CCDANCTR-References and CCDANCTR-Studies) and the Cochrane Pregnancy and Childbirth Group were searched up to 4 March 2015. These registers include relevant randomised controlled trials from the following bibliographic databases: the Cochrane Library (all years to date), MEDLINE (1950 to date), EMBASE (1974 to date), and PsycINFO (1967 to date). Additional searches were conducted in CENTRAL, MEDLINE, EMBASE, PsycINFO, and Maternity and Infant Care. The reference lists of all included studies were checked for additional published reports and citations of unpublished research. Experts in the field were contacted. Selection criteria: We included randomised controlled trials (RCTs) and quasi-randomised trials comparing postnatal debriefing interventions with standard postnatal care for the prevention of psychological trauma of women following childbirth. The intervention consisted of at least one debriefing intervention session, which had the purpose of allowing women to describe their experience and to normalise their emotional reaction to that experience. Data collection and analysis: Three authors independently assessed trial quality and extracted data. Meta-analysis was conducted where there were more than two trials examining the same outcomes. Main results: We included seven trials (eight articles) from three countries (UK, Australia and Sweden) that fulfilled the inclusion criteria. The number of women contributing data to each outcome varied from 102 to 1745. Methodological quality was variable and most of the studies were of low quality. The quality of evidence for the prevalence of psychological trauma (primary outcome) and the prevalence of depression symptoms was rated low or very low, based on few studies (ranging from a single study to three studies) with high risk of bias in main domains such as performance bias, random sequence generation, allocation concealment and incomplete outcome data. The quality of evidence for the remaining outcomes (that is prevalence of anxiety, prevalence of fear of childbirth, prevalence of general psychological morbidity, health service utilization and attrition from treatment) was not assessed as data were not available.Among women who had a high level of obstetric intervention during labour and birth, we found no difference between standard postnatal care with debriefing and standard postnatal care without debriefing on psychological trauma symptoms within three months postpartum (RR 0.61; 95% CI 0.28 to 1.31; n = 425) or at three to six months postpartum (RR 0.62; 95% CI 0.27 to 1.42; n = 246). The results were based on two trials, respectively. Among women who experienced a distressing or traumatic birth, there was no evidence of an effect of psychological debriefing on the prevention of PTSD (measured by the MINI-PTSD) at four to six weeks postpartum (RR 1.15; 95% CI 0.66 to 2.01; n = 102) or at six months (RR 0.35; 95% CI 0.10 to 1.23; n = 103). The results were based on one small trial. One trial involving low-risk women who delivered healthy infants at or near term reported no significant difference between the intervention group and the control group in the proportion of women who met the diagnostic criteria for psychological trauma during the year following childbirth (RR 1.06; 95% CI 0.88 to 1.28; n = 1745). We did not find any information about attrition rates. Authors' conclusions: We did not find any high quality evidence to inform practice, with substantial heterogeneity being found between the studies conducted to date. There is little or no evidence to support either a positive or adverse effect of psychological debriefing for the prevention of psychological trauma in women following childbirth. There is no evidence to support routine debriefing for women who perceive giving birth as psychologically traumatic.Future research should provide greater detail of the outcome measures used, and with scales for measuring psychological trauma validated against clinical diagnostic interviews. High rates of obstetric intervention in some birth settings may mean that women require improved emotional care from health professionals to reduce the risk of childbirth being experienced as traumatic. As all included trials excluded women unable to communicate in the native language of the study setting, there is no information on the response of these women to psychological debriefing. No included studies were conducted in low or middle-income countries.
    • In-hospital resuscitation

      Morrow-Barnes, Abby; Morrow-Barnes, Abby; Nursing and Midwifery Registered; South Warwickshire University NHS Foundation Trust (RCN Publishing (RCNi), 2016-11-16)
      A CPD article, on the Resuscitation Council UK guidelines for in-hospital resuscitation, improved Abby Morrow-Barnes’ knowledge of how to recognise and respond to adults in cardiac arrest.
    • Pulmonary oedema

      Morrow-Barnes, Abby; Morrow-Barnes, Abby; Nursing and Midwifery Registered; South Warwickshire University NHS Foundation Trust (RCN Publishing (RCNi), 2016-06-01)
      A CPD article refreshed Abby Morrow-Barnes’s knowledge of acute pulmonary oedema and prompted her to reflect on her practice.