The potential interaction between medical treatment and radioiodine treatment success: a systematic review
Name:
The potential interaction between ...
Size:
1.274Mb
Format:
PDF
Description:
Main article
Author
Zannat, RiazulLee, Jonathan
Muzaffar, Jameel

Read, Martin

Brookes, Katie
Sharma, Neil

Boelaert, Kristien

McCabe, Christopher J.
Nieto, Hannah

Affiliation
University of Birmingham; South Warwickshire University NHS Foundation Trust; University of Cambridge; University Hospitals Birmingham NHS Foundation TrustPublication date
2023-01
Metadata
Show full item recordAbstract
Introduction: Radioactive iodine (RAI) therapy is a critical component in the post-surgical management of thyroid cancer patients, as well as being a central therapeutic option in the treatment of hyperthyroidism. Previous work suggests that antithyroid drugs hinder the efficacy of RAI therapy in patients. However, the effects of other background medications on RAI treatment efficacy have not been evaluated. Therefore, we performed a systematic review and meta-analysis investigating the potential off-target effects of medication on RAI therapy in patients with thyroid cancer and hyperthyroidism. Methods: Systematic review and meta-analysis according to the 2020 PRISMA guidelines. Databases searched: MEDLINE, EMBASE and Cochrane Library for studies published between 2001 and 2021. Results: Sixty-nine unique studies were identified. After screening, 17 studies with 3313 participants were included. One study investigated thyroid cancer, with the rest targeted to hyperthyroidism. The majority of studies evaluated the effects of antithyroid drugs; the other drugs studied included lithium, prednisone and glycididazole sodium. Antithyroid drugs were associated with negative impacts on post-RAI outcomes (n = 5 studies, RR = 0.81, p = 0.02). However, meta-analysis found moderate heterogeneity between studies (I2 = 51%, τ2 = 0.0199, p = 0.08). Interestingly, lithium (n = 3 studies), prednisone (n = 1 study) and glycididazole (n = 1 study) appeared to have positive impacts on post-RAI outcomes upon qualitative analysis. Conclusion: Our systematic review strengthens previous work on antithyroid medication effects on RAI, and highlights that this field remains under researched especially for background medications unrelated to thyroid disease, with very few papers on non-thyroid medications published.Citation
Zannat R, Lee J, Muzaffar J, Read ML, Brookes K, Sharma N, Boelaert K, McCabe CJ, Nieto HR. The potential interaction between medical treatment and radioiodine treatment success: A systematic review. Front Endocrinol (Lausanne). 2023 Jan 4;13:1061555. doi: 10.3389/fendo.2022.1061555.Type
ArticleAdditional Links
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9845773/PMID
36686426Journal
Frontiers in EndocrinologyPublisher
Frontiers Mediaae974a485f413a2113503eed53cd6c53
10.3389/fendo.2022.1061555
Scopus Count
Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International