Author
Aurelius, TaylorMaheshwari, Ankita
Ken-Dror, Gie
Sharma, Sapna D
Amlani, Sageet
Gunathilagan, Gunaratnam
Cohen, David L
Rajkumar, Chakravarthi
Maguire, Stuart
Ispoglou, Sissi
Balogun, Ibrahim
Parry, Anthea
Sekaran, Lakshmanan
Syed, Hafiz
Lawrence, Enas
Singh, Ravneeta
Hassan, Ahamad
Wharton, Chris
Javaid, Khalid
Goorah, Neetish
Carr, Peter
Sami, Eman Abdus
Sharma, Shri Ram
Sylaja, Padmavathy N
Prasad, Kameshwar
Sharma, Pankaj
Affiliation
University of London; New Delhi & Rajendra Institute of Medical Sciences; Royal London Hospital; Queen Elizabeth the Queen Mother Hospital; Northwick Park Hospital, London; Brighton and Sussex University Hospitals NHS Trust & Brighton and University of Sussex; Bradford Teaching Hospital; Sandwell and West Birmingham NHS Trust; William Harvey Hospital; Hillingdon Hospital; Luton and Dunstable Hospital; Newham University Hospital; Croydon University Hospital; West Middlesex University; Leeds General Infirmary; The Royal Wolverhampton NHS Foundation Trust; Walsall Healthcare NHS Trust; Queen's Park Hospital Royal Blackburn; University Hospitals Birmingham NHS Foundation Trust; Airedale General Hospital; North Eastern Indira Gandhi Regional Institute for Health and Medical Sciences; Sree Chitra Tirunal Institute for Medical Sciences and Technology; Ashford & St Peter's NHS Foundation Trust; Imperial College Healthcare NHS TrustPublication date
2022-11-05
Metadata
Show full item recordAbstract
Background and purpose: Studies on stroke in South Asian populations are sparse. The aim of this study was to compare differences in age of onset of ischaemic stroke in South Asian patients living in the United Kingdom and South Asian patients living in India versus White British stroke patients. Methods: We studied the UK and Indian arms of the ongoing BRAINS study, an international prospective hospital-based study of South Asian stroke patients. The BRAINS study includes 4038 South Asian and White British patients with first-ever ischaemic stroke, recruited from sites in the United Kingdom and India. Results: Of the included patients, 1126 were South Asians living in India (ISA), while 1176 were British South Asian (BSA) and 1736 were White British (WB) UK residents. Patients in the ISA and BSA groups experienced stroke 19.5 years and 7.2 years earlier than their WB counterparts, respectively (mean [interquartile range] age: BSA 64.3 [22] years vs. ISA 52.0 [18] years vs. WB 71.5 [19] years; p < 0.001). Patients in the BSA group had higher rates of hypertension, diabetes mellitus and hypercholesterolaemia than those in the ISA and WB groups. After adjustment for traditional stroke risk factors, an earlier age of stroke onset of 18.9 years (p < 0.001) and 8.9 years (p < 0.001) was still observed in the ISA and BSA groups, respectively. In multivariable stepwise linear regression analysis, ethnicity accounted for 24.7% of the variance in early age onset. Conclusion: Patients in the BSA and ISA groups experienced ischaemic stroke approximately 9 and 19 years earlier, respectively, than their WB counterparts. Ethnicity is an independent predictor of early age of stroke onset. Our study has considerable implications for public health policymakers in countries with sizable South Asian populations.Citation
Aurelius T, Maheshwari A, Ken-Dror G, Sharma SD, Amlani S, Gunathilagan G, Cohen DL, Rajkumar C, Maguire S, Ispoglou S, Balogun I, Parry A, Sekaran L, Syed H, Lawrence E, Singh R, Hassan A, Wharton C, Javaid K, Goorah N, Carr P, Sami EA, Sharma SR, Sylaja PN, Prasad K, Sharma P; BRAINS collaborators. Ischaemic stroke in South Asians: The BRAINS study. Eur J Neurol. 2023 Feb;30(2):353-361. doi: 10.1111/ene.15605Type
ArticlePMID
36260058Journal
European Journal of NeurologyPublisher
Wileyae974a485f413a2113503eed53cd6c53
10.1111/ene.15605