Impact of perinatal factors on biomarkers of cardiovascular disease risk in preadolescent children
Author
Mansfield, RoshniCecula, Paulina
Pedraz, Carmen Traseira
Zimianiti, Ioanna
Elsaddig, Malaz
Zhao, Rebecca
Sathiyamurthy, Sundar
McEniery, Carmel M
Lees, Christoph
Banerjee, Jayanta
Publication date
2023-04-27
Metadata
Show full item recordAbstract
Background: This review aims to summarize associations of the perinatal environment with arterial biophysical properties in childhood, to elucidate possible perinatal origins of adult cardiovascular disease (CVD). Methods: A systematic search of PubMed database was performed (December 2020). Studies exploring associations of perinatal factors with arterial biophysical properties in children 12 years old or less were included. Properties studied included: pulse wave velocity; arterial stiffness or distensibility; augmentation index; intima-media thickness of aorta (aIMT) or carotids; endothelial function (laser flow Doppler, flow-mediated dilatation). Two reviewers independently performed study selection and data extraction. Results: Fifty-two of 1084 identified records were included. Eleven studies explored associations with prematurity, 14 explored maternal factors during pregnancy, and 27 explored effects of low birth weight, small-for-gestational age and foetal growth restriction (LBW/SGA/FGR). aIMT was consistently higher in offspring affected by LBW/SGA/FGR in all six studies examining this variable. The cause of inconclusive or conflicting associations found with other arterial biophysical properties and perinatal factors may be multifactorial: in particular, measurements and analyses of related properties differed in technique, equipment, anatomical location, and covariates used. Conclusion: aIMT was consistently higher in LBW/SGA/FGR offspring, which may relate to increased long-term CVD risk. Larger and longer term cohort studies may help to elucidate clinical significance, particularly in relation to established CVD risk factors. Experimental studies may help to understand whether lifestyle or medical interventions can reverse perinatal changes aIMT. The field could be advanced by validation and standardization of techniques assessing arterial structure and function in children.Citation
Mansfield R, Cecula P, Pedraz CT, Zimianiti I, Elsaddig M, Zhao R, Sathiyamurthy S, McEniery CM, Lees C, Banerjee J. Impact of perinatal factors on biomarkers of cardiovascular disease risk in preadolescent children. J Hypertens. 2023 Jul 1;41(7):1059-1067. doi: 10.1097/HJH.0000000000003452. Epub 2023 Apr 27.Type
ArticleAdditional Links
http://www.jhypertension.comPMID
37115847Journal
Journal of HypertensionPublisher
Lippincott, Williams & Wilkinsae974a485f413a2113503eed53cd6c53
10.1097/HJH.0000000000003452