The association between obesity and spontaneous temporal bone CSF leak outcomes : a systematic review and meta-analysis
Spinos, Dimitrios Geropoulos, Georgios Vavoulis, Georgios Georgountzos, Georgios Papageorgakopoulou, Manthia Karela, Nina Rafailia Varoutis, Panagiotis Evangelou, Kyriacos Cho, Wai Sum
Spinos, Dimitrios
Geropoulos, Georgios
Vavoulis, Georgios
Georgountzos, Georgios
Papageorgakopoulou, Manthia
Karela, Nina Rafailia
Varoutis, Panagiotis
Evangelou, Kyriacos
Cho, Wai Sum
Affiliation
South Warwickshire University NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; Society of Junior Doctors, Surgical Working Group, Athens, Greece; General Hospital of Thessaloniki Ippokratio, Greece; Nottingham University Hospitals NHS Trust
Other Contributors
Publication date
2024-02-24
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Objective: We undertook a systematic review of the literature with meta-analysis to identify the role of obesity (BMI ≥30) in the patient characteristics presenting with spontaneous cerebrospinal fluid (sCSF) leaks of the lateral skull base and the outcomes of their repair.
Data sources: A Systematic Review of English Articles using MEDLINE, EMBASE, and Cochrane Library.
Review methods: The research algorithm included the following keywords: "spontaneous CSF leak," "lateral skull base," "temporal bone," "meningocele," "encephalocele," and "otorrhea." We also manually searched the references of included studies, to identify possible studies missed during our literature search.
Results: More than two-thirds of the patients were female (69.2%) and often were obese (mean BMI 36.5 kg/m2) with a mean age of 57. Most common presenting symptoms were otorrhea and hearing loss. Most authors did not report a routine use of a post-operative lumbar drain. Most patients had a single skull base defect and encephaloceles prolapsing through, across obese and non-obese groups. Median length of stay in hospital was 3.2 days, and the majority of patients did not have any recurrence during their follow-up (89.6%), which was not affected by obesity.
Conclusion: Obesity does not affect length of hospital stay or recurrence rate following surgical repair of lateral skull base sCSF leaks. Surgical repair is a safe and viable approach in the management of obese patients with sCSF leaks in the temporal bone.
Level of evidence: NA Laryngoscope, 134:2012-2018, 2024.
Citation
Spinos D, Geropoulos G, Vavoulis G, Georgountzos G, Papageorgakopoulou M, Karela NR, Varoutis P, Evangelou K, Cho WS. The Association Between Obesity and Spontaneous Temporal Bone CSF Leak Outcomes: A Systematic Review and Meta-Analysis. Laryngoscope. 2024 May;134(5):2012-2018. doi: 10.1002/lary.31349. Epub 2024 Feb 24.
Type
Article