Busby, JohnMcDowell, P JanePfeffer, Paul EMansur, Adel HasanHeaney, Liam G2024-01-092024-01-092023-12-07Busby J, McDowell PJ, Pfeffer PE, Mansur AH, Heaney LG. Ethnic variation in asthma phenotypic presentation and outcomes: a cross-sectional analysis of the UK Biobank. Thorax. 2024 Jan 18;79(2):186-190. doi: 10.1136/thorax-2023-221101.0040-63761468-329610.1136/thorax-2023-22110138071553http://hdl.handle.net/20.500.14200/3339Ethnic disparities exist within asthma; however, country of birth is rarely investigated. We described demographic and clinical characteristics by ethnicity and country of birth within the UK Biobank. Lung function and asthma hospitalisations were similar for white, black and North-East Asian participants, however, South-East (SE) Asians more commonly had an FEV1 below the lower limits of normal (LLN; 53.8% vs 32.3%, p<0.001), blood eosinophilia (38.6% vs 23.8%, p<0.001) and asthma hospitalisation (12.5% vs 8.3%, p<0.001) than white participants. First-generation SE Asian immigrants had poorer lung function (57.7% vs 27.7% FEV1 below LLN, p<0.001) than UK/Ireland born participants. These data demonstrate inter-ethnic and intra-ethnic disparities.en© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.Respiratory medicineHuman physiologyArticle