Liu, XiaoxuanHui, Benjamin TkWay, ChristopherBeese, SophieAdriano, AdaKeane, Pearse AMoore, David JDenniston, Alastair K2024-09-172024-09-172020-10-06Liu X, Hui BT, Way C, Beese S, Adriano A, Keane PA, Moore DJ, Denniston AK. Noninvasive Instrument-based Tests for Detecting and Measuring Vitreous Inflammation in Uveitis: A Systematic Review. Ocul Immunol Inflamm. 2022 Jan 2;30(1):137-148. doi: 10.1080/09273948.2020.1799038. Epub 2020 Oct 60927-39481744-507810.1080/09273948.2020.179903833021418http://hdl.handle.net/20.500.14200/5778Purpose: This systematic review aims to identify instrument-based tests for quantifying vitreous inflammation in uveitis, report the test reliability and the level of correlation with clinician grading. Methods: Studies describing instrument-based tests for detecting vitreous inflammation were identified by searching bibliographic databases and trials registers. Test reliability measures and level of correlation with clinician vitreous haze grading are extracted. Results: Twelve studies describing ultrasound, optical coherence tomography (OCT), and retinal photography for detecting vitreous inflammation were included: Ultrasound was used for detection of disease features, whereas OCT and retinal photography provided quantifiable measurements. Correlation with clinician grading for OCT was 0.53-0.60 (three studies) and for retinal photography was 0.51 (1 study). Both instruments showed high inter- and intra-observer reliability (>0.70 intraclass correlation and Cohen's kappa), where reported in four studies. Conclusion: Retinal photography and OCT are able to detect and measure vitreous inflammation. Both techniques are reliable, automatable, and warrant further evaluation.enOphthalmologyArticle