Shivashri, ChockalingamDeepa, MohanGhebremichael-Weldeselassie, YonasMohan Anjana, RanjitUma, RamMohan, ViswanathanSaravanan, Ponnusamy2024-01-292024-01-292022-12-12Shivashri C, Hannah W, Deepa M, Ghebremichael-Weldeselassie Y, Anjana RM, Uma R, Mohan V, Saravanan P. Prevalence of prediabetes and type 2 diabetes mellitus in south and southeast Asian women with history of gestational diabetes mellitus: Systematic review and meta-analysis. PLoS One. 2022 Dec 12;17(12):e0278919. doi: 10.1371/journal.pone.0278919. PMID: 36508451; PMCID: PMC9744276.1932-620310.1371/journal.pone.027891936508451http://hdl.handle.net/20.500.14200/3457Background: The burden of Gestational Diabetes Mellitus (GDM) is very high in south Asia (SA) and southeast Asia (SEA). Thus, there is a need to understand the prevalence and risk factors for developing prediabetes and type 2 diabetes mellitus (T2DM) postpartum, in this high-risk population. Aim: To conduct a systematic review and meta-analysis to estimate the prevalence of prediabetes and T2DM among the women with history of GDM in SA and SEA. Methods: A comprehensive literature search was performed in the following databases: Medline, EMBASE, Web of Knowledge and CINHAL till December 2021. Studies that had reported greater than six weeks of postpartum follow-up were included. The pooled prevalence of diabetes and prediabetes were estimated by random effects meta-analysis model and I2 statistic was used to assess heterogeneity. Results: Meta-analysis of 13 studies revealed that the prevalence of prediabetes and T2DM in post-GDM women were 25.9% (95%CI 18.94 to 33.51) and 29.9% (95%CI 17.02 to 44.57) respectively. Women with history of GDM from SA and SEA seem to have higher risk of developing T2DM than women without GDM (RR 13.2, 95%CI 9.52 to 18.29, p<0.001). The subgroup analysis showed a rise in the prevalence of T2DM with increasing duration of follow-up. Conclusion: The conversion to T2DM and prediabetes is very high among women with history of GDM in SA and SEA. This highlights the need for follow-up of GDM women for early identification of dysglycemia and to plan interventions to prevent/delay the progression to T2DM.enhttps://creativecommons.org/licenses/by/4.0/EndocrinologyArticleCC BY 4.0 DEED