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Long-term effectiveness of intra-articular injectables in patients with knee osteoarthritis : a systematic review and Bayesian network meta-analysisBackground: Intra-articular injectables are proposed as a solution for pain relief and functional improvement in knee osteoarthritis (OA), however most studies involving intra-articular knee injectables are focused on short-term relief, leaving the recommendations regarding long-term management unclear. This network meta-analysis aimed to evaluate the mid- to long-term effectiveness of intra-articular knee injection of platelet-rich plasma (PRP), hyaluronic acid (HA), corticosteroids (CS), and their combinations for management of knee OA. Methods: Relevant studies were searched through PubMed, EMBASE, Scopus, and Cochrane Register of Trials databases from inception to 20th October, 2024 for randomized controlled trials (RCTs) of knee OA patients who had taken intra-articular injectable treatment with a follow-up duration of at least one year. The study included 37 RCTs involving 5089 patients. The outcomes assessed were pain relief and functional improvement of knee joint. The random effects Bayesian model was carried out for network meta-analysis. The surface under the cumulative ranking (SUCRA) curve demonstrated the rank probability of each injectable therapy for different outcomes. Results: Analysis revealed that, in terms of both knee pain relief and improvement of functional outcomes, the combined intra-articular injection of PRP and HA was ranked ahead of the isolated administration of PRP, followed by combination of HA with CS, HA alone, placebo, and CS at the end of one year. Conclusion: These findings emphasize the sustained efficacy of PRP, particularly when combined with HA, in providing superior long-term pain relief and functional improvement in knee OA compared to other intra-articular injectables, highlighting its potential as a preferred treatment modality.
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Reconstruction of a large lateral upper and lower eyelid defect using a Mitek screw, Fricke flap and skin grafts from the eyelidPeriocular basal cell carcinomas (BCC) are commonly excised and reconstructed by oculoplastic surgeons. We describe, with the aid of pictures and diagrams, a multimodal reconstruction of a large defect involving the lateral canthal angle, one-third of the upper eyelid and half of the lower eyelid with loss of lateral orbital periosteum. The eyelids were anchored with the novel use of a Prolene suture tethered to a titanium screw at the lateral orbital rim, providing structural stability. A Fricke flap was mobilised to reform the anterior lamella of the upper and lower eyelids, with the addition of an upper eyelid advancement flap and a small skin graft. The patient has had an excellent result at 15-month follow-up.
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Outcomes of cataract surgery training among ophthalmology trainees in the independent sector and within the NHSObjective: The surge in National Health Service (NHS) cataract procedures in the independent sector (IS) has reduced opportunities for cataract surgical training among ophthalmology trainees. This study aims to analyse IS cataract surgery training outcomes and explore its potential as a supplement to NHS-based training by comparing IS outcomes with NHS and National Ophthalmology Database (NOD) standards. Methods and analysis: Two trainees (ST5 and ST3) trained in IS high volume and standard NHS lists. A comprehensive IS training programme included modular cataract training, structured feedback framework and non-technical skills development. Prospective data concerning case numbers, complexity, take-over, outcomes and complication rates were collected and compared. Results: In total, 161 IS and 62 NHS cases were analysed. On average, trainees did 6 cases/12 patient lists in IS versus 3 cases/6 patient lists in NHS. IS cases had similar complexity to NHS cases (43% IS vs 35% in NHS, p=0.32, adjusted p=1). Intraoperative complications (3% IS vs 5% NHS, p=0.53, adjusted p=1) and posterior capsule ruptures (1% IS vs 0% NHS, p=0.38, adjusted p=1) were similar, aligning with NOD standards. Based on cases without any ocular comorbidity, the proportion of eyes achieving a good visual outcome (≥6/12 Snellen vision) was similar between IS (100%) and NHS (96%) (p=0.12, adjusted p=1). Surgical efficiency was maintained with all lists completed within 4 hours. Conclusion: A structured training programme on high-volume lists within IS setting provided two trainees with valuable exposure to diverse cataract cases while ensuring safety and efficiency, producing training outcomes comparable to the NHS and NOD standards. This is a pilot study, and a much larger multicentre study will be required before the widespread introduction of training in cataract surgery in the IS can be recommended.
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Avoiding never events in orthopaedics theatres : a quality improvement projectNever events in the operating room are a surgeon's nightmare, with an incidence rate of 54%. These events are highly stressful for theatre staff and significantly compromise patient safety. The aim of this project is to avoid never events in trauma and orthopaedic theatres by ensuring that theatre staff adhere to the surgical pause and imaging pause protocols through regular audits.This prospective study was conducted in both trauma and elective orthopaedic theatres. It involved theatre staff members who were not part of the surgical team. The study was designed to take place on random days across different theatres, with the operating team unaware of the audit to ensure genuine behaviour and compliance.The audits focused on observing whether the surgical and imaging pause protocols were followed correctly. These protocols are critical for verifying patient identity, the surgical site, and the specific procedure and confirming the correct imaging is available and reviewed before proceeding. Data collected and corrective actions were implemented when non-compliance was observed, and data on compliance rates were systematically collected and analysed.Preliminary results indicate a substantial increase in compliance with both the surgical and imaging pause protocols, corresponding with a reduction in the occurrence of never events. Theatre staff reported improved understanding and confidence in performing these safety checks The use of external auditors who were not part of the surgical team provided an unbiased assessment of compliance, enhancing the reliability of the findings.In conclusion, the project demonstrates that regular audits, and data collected by non-surgical team staff, significantly improve adherence to surgical and imaging pause protocols, thereby reducing the incidence of never events in trauma and orthopaedic theatres. This approach highlights the importance of continuous monitoring and education in fostering a culture of safety and precision in surgical practice.
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Corpus Spongiosum Abscess in a patient undergoing intermittent self-dilatation : a rare case reportPenile abscesses of the corpus spongiosum are rare in urology, with few documented cases. These abscesses may occur spontaneously or due to risk factors such as diabetes mellitus, intracavernosal injection therapy, tuberculosis, trauma, and perianal or intra-abdominal abscesses. This report discusses a 76-year-old man who developed a penile abscess involving the corpus spongiosum following intermittent self-dilatation. This required open drainage together with antibiotic cover to clear the infection, and follow-up in an andrology clinic found no remnant abscess. This case highlights the importance of early diagnosis and intervention in penile abscesses, typically managed with imaging, drainage, and culture-directed antibiotics. The drainage options may include open or an ultrasound-guided approach, depending on the size and location. A multidisciplinary approach is crucial, with careful follow-up to manage potential complications such as penile deviation and erectile dysfunction. Pre-procedural counseling is essential, particularly in cases involving urethral instrumentation.
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Artificial intelligence (AI) for paediatric fracture detection : a multireader multicase (MRMC) study protocolIntroduction: Paediatric fractures are common but can be easily missed on radiography leading to potentially serious implications including long-term pain, disability and missed opportunities for safeguarding in cases of inflicted injury. Artificial intelligence (AI) tools to assist fracture detection in adult patients exist, although their efficacy in children is less well known. This study aims to evaluate whether a commercially available AI tool (certified for paediatric use) improves healthcare professionals (HCPs) detection of fractures, and how this may impact patient care in a retrospective simulated study design. Methods and analysis: Using a multicentric dataset of 500 paediatric radiographs across four body parts, the diagnostic performance of HCPs will be evaluated across two stages-first without, followed by with the assistance of an AI tool (BoneView, Gleamer) after an interval 4-week washout period. The dataset will contain a mixture of normal and abnormal cases. HCPs will be recruited across radiology, orthopaedics and emergency medicine. We will aim for 40 readers, with ~14 in each subspecialty, half being experienced consultants. For each radiograph HCPs will evaluate presence of a fracture, their confidence level and a suitable simulated management plan. Diagnostic accuracy will be judged against a consensus interpretation by an expert panel of two paediatric radiologists (ground truth). Multilevel logistic modelling techniques will analyse and report diagnostic accuracy outcome measures for fracture detection. Descriptive statistics will evaluate changes in simulated patient management. Ethics and dissemination: This study was granted approval by National Health Service Health Research Authority and Health and Care Research Wales (REC Reference: 22/PR/0334). IRAS Project ID is 274 278. Funding has been provided by the National Institute for Heath and Care Research (NIHR) (Grant ID: NIHR-301322). Findings from this study will be disseminated through peer-reviewed publications, conferences and non-peer-reviewed media and social media outlets.
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A systematic review of simulation-based training tools in plastic surgeryObjectives: The recent shift from traditional surgical teaching to the incorporation of simulation training in plastic surgery has resulted in the development of a variety of simulation models and tools. We aimed to assess the validity and establish the effectiveness of all currently available simulators and tools for plastic surgery. Design: Systematic review. Methods: The PRISMA 2020 checklist was followed. The review protocol was prospectively registered in PROSPERO (CRD42021231546). Published and unpublished literature databases were searched to the 29th of October 2023. Each model was appraised in accordance with the Messick validity framework, and a rating was given for each section. To determine the effectiveness of each model, the McGaghie model of translational outcomes was used. Results: On screening 1794 articles, 116 were identified to discuss validity and effectiveness of simulation models in plastic surgery. These were hand surgery (6 studies), breast surgery (12 studies), facial surgery (25 studies), cleft lip and palate surgery (29 studies), rhinoplasty (4 studies), hair transplant surgery (1 study), surgery for burns (10 studies), and general skills in plastic surgery (29 studies). Only 1 model achieved an effectiveness level > 3, and no model had a rating > 2 in all aspects of the Messick validity framework. Conclusion: There are limited models enabling the transfer of skills to clinical practice. No models achieved reductions in surgical complications or costs. There must be more validity studies conducted using updated validity frameworks, with an increased emphasis on the applicability of these simulators to improve patient outcomes and surgical technique. More training tools evaluating both technical and non-technical surgical skills are recommended.
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The effect of visual acuity measurement on triage effectiveness in an ophthalmic emergency departmentPurpose: The effect of pre-triage visual acuity (VA) measurement on triage accuracy in a busy ophthalmic casualty department was investigated as a possible means to improve triage quality. Methods: All 576 patients attending the accident and emergency department (A&E) at the Birmingham and Midland Eye Centre (BMEC) over a period of 4 days were included in this prospective cross-sectional study. Patients were assigned to two groups: those who underwent a VA measurement prior to triage (n = 242) and a control group who did not have a VA measurement (n = 234). Clinicians who were masked from the allocation also assessed whether they agreed with the triage decision after assessing each patient. Results: Triage outcomes were recorded for 469 (81%) patients. Those with a pre-triage VA measurement were more likely to be assessed as more urgent (p = 0.005) and less likely to be discharged (p = 0.04). 248 (43%) patients had clinician response with corresponding triage records, of which 136 (55%) had prior VA measurement and 112 (45%) were in the control group. Clinicians responded that patients with VA measurement prior to triage were more accurately triaged than the control group (66% and 54%; p = 0.03). Conclusion: VA measurement prior to triage can help improve triage accuracy and allow better allocation of resources at an overcrowded eye-dedicated emergency department. However, waiting times may increase due to longer triage duration and more patients to be triaged into urgent pathway. Greater staffing resources may be necessary to complement the proposed change to avoid undermining triage efficiency.
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Assessing clinicians' documentation of vision in older adults who presented with a fall at the Accident and Emergency Department of Northampton General HospitalBackground Falls among elderly adults are one of the most common reasons that could lead to injury and modality, as vision is one of the modifiable risk factors for falls. By assessing it, we can detect those needing further follow-up with opticians or ophthalmologists, lowering the risk of falls secondary to poor vision. Methods Data were collected and reviewed retrospectively from a consecutive list of patients who presented with a fall or head injury to the Accident and Emergency Department at Northampton General Hospital. A total of 180 patients aged 75 years or older were randomly selected between November 2022 and January 2023. This audit measured the vision documentation in the vision assessment tool used in the Emergency Department at Northampton General Hospital and was based on the National Institute for Health and Clinical Excellence (NICE) and the Royal College of Physicians guidelines. Results Out of 180 patients in the sample, 34 (19%) had their visual assessments documented. Among them, around six (17.6%) out of 34 patients had a full vision assessment documenting all the sections in the vision assessment tool. Five (14.7%) out of 34 patients and 11 (32.3%) out of 34 patients did not have documentation about their distance and near vision, respectively. The visual fields were not documented in 22 (64.7%) out of 34 patients, and no assessment of the eye movements was reported in 16 (47%) out of 34 patients. Discussion Most of the patients in the Emergency Department lacked visual documentation, resulting in low compliance with the standards. One of the factors that contribute to elderly people's falling is low vision. Uncorrected refractive errors are one of the main causes of poor vision, but their correction is also associated with an increased risk of falls among elderly patients, as they require more time to adapt to changes in prescription (e.g., new glasses). In addition, patients who suffer from some eye conditions, such as glaucoma or macular degeneration, also have a high incidence of falls caused by an impairment of the visual fields. Conclusions All patients over 75 years old who presented with a fall to the Emergency Department should have a vision assessment. Vision documentation is essential to identify patients with vision impairment needing to receive an eye assessment after their discharge to reduce the risk of falls derived from poor vision. Strategies to improve this include training and the dissemination of information (for example, posters), which could help increase documentation rates.
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Understanding medical students' perceptions of failure in medical schoolThis paper explores medical students' perceptions of failure through a qualitative approach, using semi-structured interviews to gather insights from six students across different academic years at Queen Mary University of London. The study aims to understand how students define failure, its causes, and its impact on their academic and personal lives. Key findings reveal that failure is perceived as multifaceted, influenced by internal and external expectations, and evolves throughout medical school. The impact of failure is significant, affecting students' motivation, mental health, and coping mechanisms. While students sought both formal and informal support, barriers such as stigma and a lack of awareness hindered access to help. The study concludes that fostering an open dialogue on failure and integrating support systems could improve students' experiences, better preparing them for the uncertainties of clinical practice. Limitations include the small sample size and focus on a single institution. Further research is suggested to broaden the understanding of failure at different stages of medical education.
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Impact of virtual clinics on streamlining NHS outpatient waiting lists and carbon emissionsBackground: The National Health Service (NHS) outpatient waiting list is growing, affecting specialties like foot and ankle. Delays are due to increasing demand, limited resources, and administrative inefficiencies. Virtual clinics are being explored to reduce physical clinic burdens and provide timely care. This study investigates the effectiveness of virtual clinics in reducing prolonged waiting times in the foot and ankle specialty. Emissions from personal vehicles are a primary driver of climate change, which is a little recognized benefit of virtual clinics. Methods: We analyzed outcomes from a virtual elective foot and ankle clinic, overseen by a specialist consultant, for new elective referrals over 4 months. Data for 175 patients were collected from Lorenzo, our electronic health records system. We also assessed the success rate of virtual consultations in terms of accurate diagnoses and effective treatment plans. Measured distance to the hospital based was on patients' residential address. Results: The virtual clinic effectively managed patients. Of the 175 patients, 48.6% completed treatment, and were discharged, and 53.7% were managed without face-to-face consultations. In addition, 66.3% did not need in-person visits; this includes patients treated and discharged and who were referred for investigations. In this clinic, avoiding 1 visit to the hospital by 116 patients saved travel of 1040 miles. Conclusion: The widespread adoption of virtual clinics can provide a convenient and cost-effective health care solution for patients and also potentially help reduce carbon emissions contributing to control global warming. Level of evidence: Level IV, retrospective case series.
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Weight bearing versus non-weight bearing total contact cast in the management of active Charcot foot : a systematic reviewAim: Diabetic Charcot neuro-osteoarthropathy carries a significant worldwide disease burden including diabetic foot infection, ulceration and amputation. The current accepted standard of treatment during the active phase of Charcot neuro-osteoarthropathy is offloading with total contact casting; however, controversy remains regarding weight-bearing status during this period. Methods: A systematic review was performed following PRISMA guidelines of Pubmed, EMBASE, MEDLINE and the Cochrane central register of controlled trials for clinical studies from inception until June 2024 investigating weight-bearing and non-weight-bearing total contact casting for active Charcot neuro-osteoarthropathy. Results: Four hundred ninety-three studies were identified in the search strategy of which 5 studies met the inclusion criteria comprising 158 patients. These studies found that allowing patients to weight-bear during total contact casting does not have a negative impact on the healing process. There were no comparative studies between weight-bearing and non-weight-bearing total contact casting. Conclusions: There is limited evidence to support current practice of non-weight bearing in a total contact casting for active Charcot neuro-osteoarthropathy. Allowing patients to weight bear carries advantages to patient independence and quality of life. Further investigation with randomised control trial should be considered to investigate if weight bearing is associated with negative outcomes.
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Surgical versus conservative management of delayed presentation of acute biliary disease : a systematic literature reviewBiliary sepsis, characterized by contamination and infection of the biliary tract, poses a serious medical issue with detrimental effects on the patients. While cholecystectomy is the usual treatment for symptomatic gallstones, the most desirable management approach for biliary sepsis remains debated, prompting a scientific evaluation of the long-term effects of cholecystectomy. To compare the long-term outcomes of biliary sepsis in patients undergoing cholecystectomy versus conservative management (CM), this study will systematically review the existing literature to clarify differences in recurrence rates, complication rates, and overall survival. PubMed and the Cochrane Library were searched thoroughly for the literature review. Studies were included if they reported the effects of surgical and conservative interventions on predefined patient outcomes. A critical appraisal of the studies included was performed using CASP criteria. Fourteen studies were included, comprising prospective cohort studies and randomized controlled trials, with sample sizes varying from 52 to 234 patients. Endoscopic sphincterotomy (ES), early versus delayed laparoscopic cholecystectomy (D-LC), combined endoscopic-laparoscopic techniques, and percutaneous cholecystostomy followed by early laparoscopic cholecystectomy (E-LC) were the analyzed interventions. The primary conclusions showed that, in comparison to D-LC, E-LC significantly reduced hospital stays (p < 0.05), since the times were 58 and 167 hours for E-LC and D-LC, respectively. Additionally, E-LC resulted in fewer recurrent biliary events (4.3 compared to 36.2% of D-LC) and lower overall costs. ES demonstrated efficacy in mitigating the requirement for emergency cholecystectomy in patients at high risk, as evidenced by its 94% success rate in endoscopic stone removal. Without increasing postoperative complications, combined endoscopic-laparoscopic techniques showed high success rates for stone removal (95.6% common bile duct clearance rate). This systematic review highlights the favorable long-term effects of cholecystectomy in managing biliary sepsis. It emphasizes the importance of individualized treatment processes and considers conservative control for patients with high surgical risk and significant comorbidities. It also highlights the need for advancement in CM and provides insights that can help clinical decision-making to optimize outcomes in affected patients.
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Evaluation of mesh closure of laparotomy and extraction incisions in open and laparoscopic colorectal surgery : a systematic review and meta-analysisBackground and Objectives: Evisceration and incisional hernia (IH) represent a significant morbidity following open or laparoscopic colorectal surgery where midline laparotomy or extraction incision (EI) are performed. We executed a systematic review to evaluate primary mesh closure of laparotomy or EI in colorectal resections of benign or malignant conditions. Methods: A comprehensive literature search was performed using PubMed, Science Direct, Cochrane, and Google Scholar databases for studies comparing prophylactic mesh to traditional suture techniques in closing laparotomy in open approach or EI when minimally invasive surgery was adopted in colorectal procedures, regardless of the diagnosis. Both IH and evisceration were identified as primary outcomes. Secondary outcomes included surgical site infections (SSI), postoperative seroma, and length of hospital stay (LOS). Results: Six studies were included in our analysis with a total population of 1398 patients, of whom 411 patients had prophylactic mesh augmentation when closing laparotomy or EI, and 987 underwent suture closure. The mesh closure group had a significantly lower risk of developing IH compared to the conventional closure group (OR 0.23, p = 0.00001). This result was significantly consistent in subgroup analysis of open laparotomy or EI of laparoscopic surgery subgroups. There was no statistically notable difference in evisceration incidence (OR 0.51, p = 0.25). Secondary endpoints did not significantly differ between both groups in terms of SSI (OR 1.20, p = 0.54), postoperative seroma (OR 1.80, p = 0.13), and LOS (MD -0.54, p = 0.63). Conclusions: primary mesh reinforcement of laparotomy or EI closure in colorectal resections lessens IH occurrence. No safety concerns were identified; however, further high-quality research may provide more solid conclusions.
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Ambulatory management of acute uncomplicated diverticulitis (AmbUDiv study) : a multicentre, propensity score matching studyIntroduction: Recent studies have suggested that ambulatory management is feasible for acute uncomplicated diverticulitis (AUD); however, there is still no consensus regarding the most appropriate management settings. This study presents a multi-centre experience of managing patients presenting with AUD, specifically focusing on clinical outcomes and comparing ambulatory treatment with in-patient management. Methods: A retrospective multi-centre study was conducted across four hospitals in the UK and included all adult patients with computed tomography (CT) confirmed (Hinchey grade 1a) acute diverticulitis over a 12-month period (January - December 2022). Patient medical records were followed up for 1-year post-index episode, and outcomes were compared between those treated through the ambulatory pathway versus inpatient treatment using 1:1 propensity score matching (PSM). All statistical analysis was performed using the R Foundation for Statistical Computing, version 4.4. Results: A total of 348 patients with Hinchey 1a acute diverticulitis were included (260 in-patients; 88 ambulatory pathway), of which nearly a third (31.3%) had a recurrent disease. Inpatient management was dominant (74.7%), with a median of 3 days of hospital stay. PSM resulted in 172 patients equally divided between the two care settings. Ambulatory management was associated with a lower readmission rate (P = 0.02 before PSM, P = 0.08 after PSM), comparable surgical (P = 0.57 before PSM, 0% in both groups after PSM) and radiological interventions (P = 0.99 before and after PSM) within one year. In both matched and non-matched groups, a strong association between readmissions and inpatient management was noted in univariate analysis (P = 0.03 before PSM, P = 0.04 after PSM) and multivariate analysis (P = 0.02 before PSM, P = 0.03 after PSM). Conclusion: Our study supports the safety and efficacy of managing patients with AUD through a well-designed ambulatory care pathway. In particular, hospital re-admission rates are lower and other outcomes are non-inferior to in-patient treatment. This has implications for substantial cost-savings and better utilisation of limited healthcare resources.
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Hand Osteomyelitis : a systematic review of the literature and recommendations for diagnosis and managementHand osteomyelitis is a complex condition to diagnose and treat, with an opportunity to improve care through organization of existing evidence. The literature was systematically searched for series of hand osteomyelitis between 1990 and 2022 for evidence regarding diagnosis and treatment, to formulate recommendations. Twenty-one series reported at least 5 cases of hand osteomyelitis in adults, with a total of 666 cases. Surgical debridement is central to treatment and oral antibiotics are sufficient for individuals without diabetes, renal or vascular disease, after debridement and resolution of associated sepsis. A 4- to 6-week duration of antibiotic therapy according to organism sensitivities is recommended, or a 2-week course after amputation. Delayed presentation is common and if over 6 months is associated with high amputation rates. Hand osteomyelitis with renal failure is associated with systemic complications. Reconstruction options include antibiotic-eluting spacers, osteosynthesis or arthrodesis, vascularized bone or adipose, regional soft tissue coverage and silicone implant arthroplasty.Level of Evidence: IV.
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Artificial intelligence chatbots as sources of patient education material for cataract surgery : ChatGPT-4 versus Google BardObjective: To conduct a head-to-head comparative analysis of cataract surgery patient education material generated by Chat Generative Pre-trained Transformer (ChatGPT-4) and Google Bard. Methods and analysis: 98 frequently asked questions on cataract surgery in English were taken in November 2023 from 5 trustworthy online patient information resources. 59 of these were curated (20 augmented for clarity and 39 duplicates excluded) and categorised into 3 domains: condition (n=15), preparation for surgery (n=21) and recovery after surgery (n=23). They were formulated into input prompts with 'prompt engineering'. Using the Patient Education Materials Assessment Tool-Printable (PEMAT-P) Auto-Scoring Form, four ophthalmologists independently graded ChatGPT-4 and Google Bard responses. The readability of responses was evaluated using a Flesch-Kincaid calculator. Responses were also subjectively examined for any inaccurate or harmful information. Results: Google Bard had a higher mean overall Flesch-Kincaid Level (8.02) compared with ChatGPT-4 (5.75) (p<0.001), also noted across all three domains. ChatGPT-4 had a higher overall PEMAT-P understandability score (85.8%) in comparison to Google Bard (80.9%) (p<0.001), which was also noted in the 'preparation for cataract surgery' (85.2% vs 75.7%; p<0.001) and 'recovery after cataract surgery' (86.5% vs 82.3%; p=0.004) domains. There was no statistically significant difference in overall (42.5% vs 44.2%; p=0.344) or individual domain actionability scores (p>0.10). None of the generated material contained dangerous information. Conclusion: In comparison to Google Bard, ChatGPT-4 fared better overall, scoring higher on the PEMAT-P understandability scale and exhibiting more faithfulness to the prompt engineering instruction. Since input prompts might vary from real-world patient searches, follow-up studies with patient participation are required.
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Pathophysiological Aspects of Ocular Toxoplasmosis: Host-parasite Interactions.Purpose: This review aims to present the state of the art to understand the pathophysiology of ocular toxoplasmosis (OT), providing further foundations that would help to improve the future treatment and prognosis of this potentially blinding disease. Methods: A thorough literature search was performed in PubMed database. An additional search was made in Google Scholar to complete the collected items. Results: Toxoplasma gondii ocular infection is one of the most frequent causes of posterior uveitis. Despite the ocular barriers, the parasite reaches the eye through different mechanisms. Once inside, it remains encysted livelong within the retina, and recurrences cannot be completely avoided. The complexity of host-parasite interactions, leading to the success of this parasite, encompasses host factors such as genetic predisposition, immune status, and age; and parasite factors such as strain diversity, virulence, phylogenetic origin, and geographical distribution. These factors influence the clinical presentation, course, and progression of the disease. Additional elements, such as pregnancy, eating behavior, and environmental, social, and cultural factors may also contribute to this complex balance. Conclusions: The host-parasite interaction in OT is a complex and multifactorial relationship, with the parasite always on the driving edge of the game. There are still multiple incompletely understood fields to be investigated. Future research would permit further insight into the immune-biology of the parasite and recognition of the host-parasite interplay to improve the diagnostic and management performance.