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Low preoperative serum albumin levels are associated with impaired outcome after cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal surface malignancies
Seretis, Charalampos Gill, Jagjit Malik, Adnan Elhassan, Ali Mohamed Shariff, Umar Youssef, Haney
Seretis, Charalampos
Gill, Jagjit
Malik, Adnan
Elhassan, Ali Mohamed
Shariff, Umar
Youssef, Haney
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George Eliot Hospital NHS Trust, Nuneaton; Good Hope Hospital, Birmingham
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Publication date
2020-12-18
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Abstract
Preoperative hypoalbuminemia is known to be associated with postoperative morbidity and mortality, as well as with poor survival after gastrointestinal cancer surgery. However, limited data exist regarding the prognostic significance of hypoalbuminemia in patients with peritoneal metastases undergoing cytoreductive surgery, combined with perioperative intraperitoneal chemotherapy. We performed a systematic literature review of the previously published studies addressing the potential association between preoperative albumin levels and overall surgical outcomes after the performance of cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal surface malignancies. Our research yielded a total of nine retrospective studies which met our inclusion criteria, and despite their heterogeneity; and we can conclude that preoperatively low albumin levels are associated with greater likelihood of overall and major morbidity, as well as less favorable oncological outcome after the performance of cytoreductive surgery and perioperative intraperitoneal chemotherapy.
Citation
Seretis C, Gill J, Malik A, Elhassan AM, Shariff U, Youssef H. Low Preoperative Serum Albumin Levels Are Associated With Impaired Outcome After Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Peritoneal Surface Malignancies. J Clin Med Res. 2020 Dec;12(12):773-779. doi: 10.14740/jocmr4362. Epub 2020 Dec 18.
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